The traditional pharmaceutic formulation of any dosage figure involving trial and error methodology is time-consuming, costly, and inconsistent. The design of experiments has been suggested as a statistical optimisation method for studying the interaction between independent and dependent variables. The DoE provides the most meaningful information and cooperation between variables in the minimum number of runs.
The objective of the present study is to develop the best formulation of CSO loaded nanoemulsion for epidermal delivery. Optimisation of formulation requires the identification of the nanoemulsion variables affecting its characteristics, including particle size, polydispersity index, turbidity and stability evaluation. By encapsulating the CSO into a nanoemulsion, it could offer better bioavailability, antioxidant and wound healing activity.
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